One-pot regioselective vinylation of tetrazoles: preparation of 5-substituted 2-vinyl-2H-tetrazoles

The one-pot regioselective preparation of 5-aryl/alkyl-2-vinyl-2H-tetrazoles from 5-substituted tetrazoles via a very simple procedure using 1,2-dibromoethane and triethylamine without the need of any catalyst is described. The mechanism of this reaction is also discussed.

The one-pot regioselective preparation of 5-aryl/alkyl-2-vinyl-2H-tetrazoles from 5-substituted tetrazoles via a very simple procedure using 1,2-dibromoethane and triethylamine without the need of any catalyst is described.