کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5270386 | 1385415 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Facile and efficient addition of terminal alkynes to benzotriazole esters: synthesis of d-erythro-sphingosine using ynones as the key intermediate
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
From the perspective of synthesis, ynones are compounds of considerable interest because of their occurrence in a wide variety of biologically active molecules and as key synthetic intermediates. In this context, a facile and highly efficient synthesis of ynones was developed based on the high reactivity of benzotriazole esters formed in situ. Lithium acetylides can alkylate various carboxylic acids in yields ranging from 60% to 92%. To determine whether our methodology is useful for synthesising complex and biologically relevant molecules, we synthesise d-erythro-sphingosine in four steps and with 33% overall yield from l-serine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 54, Issue 52, 25 December 2013, Pages 7111-7114
Journal: Tetrahedron Letters - Volume 54, Issue 52, 25 December 2013, Pages 7111-7114
نویسندگان
José Antonio Morales-Serna, Alejandro Sauza, Gabriela Padrón de Jesús, Rubén Gaviño, Gustavo GarcÃa de la Mora, Jorge Cárdenas,