کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5270425 | 1385416 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of marchantin C, a novel microtubule inhibitor from liverworts
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of marchantin C, a novel microtubule inhibitor from liverworts Synthesis of marchantin C, a novel microtubule inhibitor from liverworts](/preview/png/5270425.png)
چکیده انگلیسی
Recently, remarkable microtubule inhibitor and anti-tumor activities of the bisbibenzyl marchantin C-isolated from liverworts like Marchantia polymorpha since 1983-were found. In this Letter we describe the first and efficient total synthesis of this subtype of bisbibenzylic compounds with two biarylether connections. The structure was confirmed by the spectroscopic data which were analyzed carefully to exclude any errors in arene connection and substitution pattern.
Marchantin C, a natural product from liverworts was now found to be highly active. We present the first total synthesis of this macrocyclic (bis)biarylether compound.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 51, Issue 22, 2 June 2010, Pages 2986-2989
Journal: Tetrahedron Letters - Volume 51, Issue 22, 2 June 2010, Pages 2986-2989
نویسندگان
Andreas Speicher, Judith Holz,