A facile one-step synthesis of 5-chloro-imidazo[1,5-a]quinazoline by microwave irradiation

A new and facile method has been developed for the one-step synthesis of 5-chloro-imidazo[1,5-a]quinazoline by cyclization of N-acylanthranilic acid A with 2-amino acetamide B1 or 2-amino-acetonitrile B2 in the presence of POCl3 under microwave irradiation. 5-chloro-imidazo[1,5-a]quinazolines can be further functionalized by displacement of 5-Cl group.

A new and facile method has been developed for the one-step synthesis of 5-chloro-imidazo[1,5-a]quinazoline by cyclization of N-acylanthranilic acid A with 2-amino acetamide B1 or 2-amino-acetonitrile B2 in the presence of POCl3 under microwave irradiation. 5-chloro-imidazo[1,5-a]quinazolines can be further functionalized by displacement of 5-Cl group.Figure optionsDownload as PowerPoint slide