Recent advance in transition-metal-mediated trifluoromethylation for the construction of C(sp3)-CF3 bonds

- We focus on the cases of transition-metal-mediated C(sp3)-CF3 bond formation.
- Trifluoromethylation of sp3-hybridized C-X bonds.
- Trifluoromethylation of alkyl organometallic reagents.
- Trifluoromethylation of sp3-hybridized C-H Bonds.
- Trifluoromethylation of alkene to form C(sp3)-CF3 bonds.

In the past 5 years, transition-metal-mediated trifluoromethylation for the construction of various CF3-containing building blocks has been the focus of recent research in both industrial and academic communities. Progresses in the construction of C(sp2)-CF3 bonds and C(sp)-CF3 have been well reviewed. This Letter will focus on the cases of transition-metal-mediated C(sp3)-CF3 bond formation, which involves the trifluoromethylation of sp3-hybridized C-X bonds, alkyl organometallic reagents, sp3-hybridized C-H bonds, and alkene derivatives.