کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5271095 | 1385432 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ugi three-component coupling reaction for the synthesis of 2-(6-oxo-11-phenyl-7,8-dihydrobenzo[b]pyrrolo[1,2-d][1,4]diazocin-5(6H)-yl)-2-phenylacetamide derivatives
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Ugi three-component coupling reaction for the synthesis of 2-(6-oxo-11-phenyl-7,8-dihydrobenzo[b]pyrrolo[1,2-d][1,4]diazocin-5(6H)-yl)-2-phenylacetamide derivatives Ugi three-component coupling reaction for the synthesis of 2-(6-oxo-11-phenyl-7,8-dihydrobenzo[b]pyrrolo[1,2-d][1,4]diazocin-5(6H)-yl)-2-phenylacetamide derivatives](/preview/png/5271095.png)
چکیده انگلیسی
- It is a three-component, four center Ugi reaction.
- It is very useful to technique to construct eight-membered pyrrolo[1,2-d][1,4]diazacines.
- It involves a bifunctional amine tethered carboxylic acid based 3CC reaction.
- It provides an easy access to generate combinatorial libraries of pyrrolo[1,2-d][1,4]diazacines for drug discovery.
A three-component, four center Ugi reaction of 3-(1-(2-aminophenyl)-5-phenyl-1H-pyrrol-2-yl)propanoic acid with aromatic aldehyde and t-butyl isocyanide has been achieved to produce a novel class of N-tert-butyl-2-(6-oxo-11-phenyl-7,8-dihydrobenzo[b]pyrrolo[1,2-d][1,4]diazacine-5(6H)-yl)-2-phenylacetamides in moderate to good yields.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 55, Issue 3, 15 January 2014, Pages 657-661
Journal: Tetrahedron Letters - Volume 55, Issue 3, 15 January 2014, Pages 657-661
نویسندگان
P. Lakshmi Reddy, D. Ashok Kumar, M. Lakshmi Devi, T. Veera Reddy, B.V. Subba Reddy, R. Narender,