کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5271212 | 1385435 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Construction of quaternary carbon centers by using substitution of γ,γ-disubstituted secondary allylic picolinates with alkylcopper reagents
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
ZnI2 was found to promote regio- and stereoselective substitution of γ,γ-disubstituted secondary allylic picolinates with alkylcopper reagents derived from alkyl-MgBr and CuBr·Me2S in a 2:1 ratio to furnish quaternary carbon centers in good yields. Alkyl groups delivered efficiently were the primary, secondary, and benzyl classes such as Me, Et, Bu, C16H33, Ph(CH2)2, Ph(CH2)3, c-C6H11, and Bn. As an application, allylic picolinates with the (E)- or (Z)-olefin afforded quaternary carbon centers that are the enantiomers of each other.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 54, Issue 35, 28 August 2013, Pages 4629-4632
Journal: Tetrahedron Letters - Volume 54, Issue 35, 28 August 2013, Pages 4629-4632
نویسندگان
Chao Feng, Yuki Kaneko, Yuichi Kobayashi,