کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5271343 1385437 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The potential of N-alkoxymethyl groups as peptide backbone protectants
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
The potential of N-alkoxymethyl groups as peptide backbone protectants
چکیده انگلیسی

In this study, the potential of N-alkoxymethyl groups as protectants for the peptide backbone has been investigated. These groups were found to be compatible with the standard conditions of Fmoc/tBu SPPS, and can be cleaved off from the peptide backbone by acids. Thus, backbone N-alkoxymethyl groups may be useful to prevent undesired side-reactions and/or interchain aggregation during peptide elongation on the solid-phase. However, the main issue for their application as protecting groups is the difficulty to incorporate them into the peptide backbone.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 55, Issue 1, 1 January 2014, Pages 184-188
نویسندگان
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