FeCl3/PPh3-catalyzed Sonogashira coupling reaction of aryl iodides with terminal alkynes

Conditions for a FeCl3/PPh3-catalyzed and palladium-, copper-, amine free-Sonogashira coupling reaction of aryl halides with terminal alkynes are reported. The protocol was applicable to a wide variety of substituted aryl iodides and alkynes with different steric and electronic properties and gave excellent yields of the desired coupling products.

Conditions for a FeCl3/PPh3-catalyzed and palladium-, copper-, amine free-Sonogashira coupling reaction of aryl halides with terminal alkynes are reported.