Palladium-catalyzed C-C coupling: efficient preparation of new 5-thio-β-d-xylopyranosides as oral venous antithrombotic drugs

First examples of a Suzuki and Stille cross-coupling reaction to prepare derivatives of pyridinyl 5-thio-β-d-xylopyranosides are described. Some of these compounds are orally active in an animal model of venous thrombosis.

Suzuki and Stille coupling reactions were first used to prepare derivatives of pyridinyl 5-thio-β-d-xylopyranosides.