کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5272706 | 1385470 | 2012 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
New multicomponent domino reaction on water: highly diastereoselective synthesis of spiro[indoline-3,4â²-pyrazolo[3,4-b]pyridines] catalyzed by NaCl
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A direct and efficient approach for the preparation of medicinally promising pyrazolopyridinyl spirooxindoles has been developed through a sequential one-pot, three-component reaction of easily available isatin, α-cyanoacetic ester or malononitrile, and 5-amino-3-methylpyrazole catalyzed by sodium chloride in water. Desired products were obtained in high to excellent yields using a simple workup procedure. The product synthesized using α-cyanoacetic ester showed high diastereoselectivity in which the stereochemistry of major diastereomer was confirmed by X-ray diffraction analysis. The present green synthesis shows attractive characteristics such as the use of water as the reaction medium, one pot conditions, short reaction period, easy workup/purification, and reduced waste production, without use of any acid or metal promoters.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 53, Issue 24, 13 June 2012, Pages 3012-3017
Journal: Tetrahedron Letters - Volume 53, Issue 24, 13 June 2012, Pages 3012-3017
نویسندگان
Anshu Dandia, Ashok kumar Laxkar, Ruby Singh,