Sulfation of β-resorcylic acid esters-first synthesis of zearalenone-14-sulfate

The chemical sulfation of β-resorcylic acid esters was investigated by applying state of the art procedures for the synthesis and deprotection of 2,2,2-trichloroethyl protected sulfates as appropriate intermediates. The selectivity of monosulfation was studied and reaction optimization was performed considering the effect of the solvent, different bases as well as the sulfation reagent itself. Finally the obtained protocols were applied for the first synthesis of zearalenone-14-sulfate (ammonium salt), an important conjugated (masked) mycotoxin, as reference material for further investigations in the field of bioanalytics as well as toxicology.