کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5273300 | 1385487 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A substrate for the detection of broad specificity α-l-arabinofuranosidases with indirect release of a chromogenic group
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
The synthesis of a compound containing a 4-nitrocatechol bound to two vicinal α-l-arabinofuranosyl moieties through a linker arm was achieved using a sulfate protecting group to facilitate selective alkylation of one aromatic hydroxyl. Several α-l-arabinofuranosidases displaying different selectivities were tested and a simple microtiter plate-based assay was developed. The observed resistance of the compound to α-l-arabinofuranosidase-mediated hydrolysis makes it suitable for the identification of enzymes that are able to accommodate bis-arabinofuranosylated moieties.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 54, Issue 24, 12 June 2013, Pages 3063-3066
Journal: Tetrahedron Letters - Volume 54, Issue 24, 12 June 2013, Pages 3063-3066
نویسندگان
Vinciane Borsenberger, Emmie Dornez, Marie-Laure Desrousseaux, Christophe M. Courtin, Michael J. O'Donohue, Régis Fauré,