An efficient synthesis of novel 2,4-disubstituted tetrahydroquinolines and quinolines

A series of novel tetrahydroquinolines have been synthesized via the acid-catalyzed reaction of an azaflavan-4-ol with a variety of reactive nucleophiles. The tetrahydroquinolines were found to undergo oxidation in the presence of iodine as catalyst to generate the corresponding novel 2,4-disubstituted quinolines.

Figure optionsDownload as PowerPoint slide