Chemically bonded cationic β-cyclodextrin derivatives as chiral stationary phases for enantioseparation applications

Vinylene-functionalized cationic β-cyclodextrins are co-polymerized with vinylized silica in the presence of AIBN and conjugated monomers. The chemically immobilized cationic β-cyclodextrins were thereafter applied as chiral stationary phases in packed column supercritical fluid chromatography and demonstrated good and reproducible enantioseparations of racemic pharmaceutical compounds.