کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5273569 | 1385493 | 2009 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: New Gilman-type lithium cuprate from a copper(II) salt: synthesis and deprotonative cupration of aromatics New Gilman-type lithium cuprate from a copper(II) salt: synthesis and deprotonative cupration of aromatics](/preview/png/5273569.png)
Deprotonative cupration of aromatics including heterocycles (anisole, 1,4-dimethoxybenzene, thiophene, furan, 2-fluoropyridine, 2-chloropyridine, 2-bromopyridine, and 2,4-dimethoxypyrimidine) was realized in tetrahydrofuran at room temperature using the Gilman-type amido-cuprate (TMP)2CuLi in situ prepared from CuCl2·TMEDA through successive addition of 1 equiv of butyllithium and 2 equiv of LiTMP. The intermediate lithium (hetero)arylcuprates were evidenced by trapping with iodine, allyl bromide, methyl iodide, and benzoyl chlorides, the latter giving the best results. Symmetrical dimers were also prepared from lithium azine and diazine cuprates using nitrobenzene as an oxidative agent.
Deproto-cupration of aromatics including heterocycles using the Gilman-type amido-cuprate (TMP)2CuLi is described.
Journal: Tetrahedron Letters - Volume 50, Issue 49, 9 December 2009, Pages 6787-6790