Copper(І) hexafluorophosphate: a dual functional catalyst for three-component reactions of methyl phenyldiazoacetate with alcohols and aldehydes or α-ketoesters

Oxonium ylides in situ generated from methyl phenyldiazoacetate and alcohols in the presence of CuPF6(CH3CN)4 underwent an aldol-type reaction with aldehydes or α-ketoesters in a convergent, three-component fashion to give α-alkoxyl-β-hydroxyl acid derivatives in good yields.

Oxonium ylides in situ generated from methyl phenyldiazoacetate and alcohols in the presence of CuPF6(CH3CN)4 underwent an aldol-type reaction with aldehydes or α-ketoesters in a convergent, three-component fashion to give α-alkoxyl-β-hydroxyl acid derivatives in good yields.Figure optionsDownload as PowerPoint slide