Borrowing hydrogen methodology for the conversion of alcohols into N-protected primary amines and in situ deprotection

Alcohols have been converted into a range of protected amines including sulfonamides and N-alkylbenzylamine derivatives. Representative examples of deprotection to afford primary amines are also provided.

Alcohols have been converted into a variety of protected amines using ruthenium-catalysed borrowing hydrogen methodology. Representative examples have been deprotected leading to an overall conversion of ROH into RNH2.