Aminomethylation of lithiated nicotinamide: access to new pyridolactams

New 2,3-dihydropyrrolopyridinones were conveniently prepared by trapping lithiated pyridine carboxamides with highly reactive formimines. In this Letter, we report that a wide range of N-functionalised compounds can be synthesised in one step by this process, allowing the presence of ethers, acetals or ester moieties.

New 2,3-dihydropyrrolopyridinones were prepared by trapping lithiated pyridine carboxamides with highly reactive formimines. This method allowed a wide range of N-functionalised compounds including ethers, acetals or ester moieties.