کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5274640 1385516 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stereoselective synthesis of the dolastatin units by organotrifluoroborates additions to α-amino aldehydes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Stereoselective synthesis of the dolastatin units by organotrifluoroborates additions to α-amino aldehydes
چکیده انگلیسی

Dolastatin units were synthesized from the 1,2-addition reactions of potassium allyl or crotyltrifluoroborate salts to aldehyde derivatives from natural amino acids. The reactions were carried out in presence of a phase-transfer catalyst in a biphasic medium at room temperature and excellent yields (>89-93%) and stereoselective (>90:10 to 98:2) were obtained. The dolastatin units 8 and 14a-b were obtained after three steps in good overall yields (50-62%).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 49, Issue 1, 1 January 2008, Pages 16-19
نویسندگان
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