A domino protocol for the efficient synthesis of structurally diverse benzothiazolylquinoline-2,5-diones and their spiro analogues

Structurally diverse benzothiazolylquinoline-2,5-diones and their spiro analogues have been synthesized by an environmentally benign efficient and convenient synthetic method involving sulfamic acid catalyzed one-pot four-component reaction of Meldrum acid, 2-aminobenzothiazoles, dimedone, and isatin/carbonyl compound.

Structurally diverse benzothiazolylquinoline-2,5-diones and their spiro analogues have been synthesized by an environmentally benign efficient and convenient synthetic method involving sulfamic acid catalyzed one-pot four component reaction of Meldrum acid 1, 2-aminobenzothiazoles 2, dimedone 6, and isatin 8/carbonyl compound 3.