T3P®-DMSO mediated one pot cascade protocol for the synthesis of 4-thiazolidinones from alcohols

Propylphosphonic anhydride (T3P®)-DMSO mediated oxidation of alcohols to carbonyl compounds and their subsequent cyclization with aryl/hetero aryl amines and thioglycolic acid to afford 4-thiazolidinones has been reported. Synthesis of 4-thiazolidinones directly from alcohols has been carried out for the first time. Mild reaction conditions, wide functional group tolerance, ease of work-up, and good yields are the noteworthy features of this protocol.

R1, R2 = H/Alkyl/Aryl/Heteroaryl and R3 = Aryl/Heteroaryl.