Synthesis of dictyomedins using phosphazene base catalyzed diaryl ether formation

Dictyomedins isolated from dictyostelium cellular slime molds were synthesized by using diaryl ether derivatives as key intermediates for the cyclization to dibenzofuran followed by palladium catalyzed intramolecular biaryl formation.

Dictyomedins isolated from dictyostelium cellular slime molds were synthesized by using phosphazene catalyzed diaryl ether formation as a key step.