A novel and convenient copper-catalyzed three-component coupling of aldehydes, alkynes, and hydroxylamines leading to propargylamines

The first copper-catalyzed direct three-component coupling reaction of aldehydes, alkynes, and hydroxylamines for the synthesis of propargylamines has been developed under mild conditions, which has the advantages of ready availability of catalyst as well as operation simplicity. The present protocol provides an appealing alternative for the construction of propargylamines in a simple and one-pot procedure.

The first copper-catalyzed direct three-component coupling reaction of aldehydes, alkynes, and hydroxylamines for the synthesis of propargylamines has been developed in a simple and one-pot procedure.