Practical route for N,O-heteroatom interchange in 3,5-disubstituted-4-nitroisoxazoles

Reaction of 3-methyl-4-nitro-5-alkylisoxazoles with hydroxylamine provides a practical means to interchange the N,O-heteroatoms on the isoxazole core thereby expanding the range of compounds obtainable from 3-methyl-4-nitro-5-styrylisoxazoles.