A novel ring-opening based tandem domino process of an activated vinyl cyclopropane

An activated vinyl cyclopropane reacted with substituted benzaldehydes to afford α-methylene γ-butyrolactones in the presence of DABCO·6H2O. This tandem domino process took place in aqueous media, and was presumably initiated with the ring opening of cyclopropane by the nucleophilic addition of DABCO·6H2O.

Figure optionsDownload as PowerPoint slide