کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5275490 1385535 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Solution-phase parallel synthesis of highly diverse spiroisoxazolinohydantoins
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Solution-phase parallel synthesis of highly diverse spiroisoxazolinohydantoins
چکیده انگلیسی

Practical and efficient solution-phase parallel synthesis of spiroisoxazolinohydantoins under mild conditions has been developed. This spiroisoxazolinohydantoin skeleton possesses three diversity points. The key intermediate, exo-methylenehydantoin bearing two positions of diversification, is prepared via a one-pot synthetic route from N-substituted methyl ester serine. Employing various alkyl halides, isocyanates, and oximes, this chemistry is applied in the generation of an 18-member demonstration library with high yield, high purity and excellent regioselectivity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 49, Issue 6, 4 February 2008, Pages 1008-1011
نویسندگان
, ,