کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5275722 | 1385540 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Design and synthesis of angucyclinone AB-pyrido[2,3-d] pyrimidine analogues Design and synthesis of angucyclinone AB-pyrido[2,3-d] pyrimidine analogues](/preview/png/5275722.png)
The preparation of two pyrimido[4,5-c]isoquinoline-7,10-quinones from acylhydroquinones and 1,3-dimethyl-5-aminouracil and their cycloadditions with 1-trimethylsilyloxybutadiene and 1-dimethylamino-3-methyl-1-azabutadiene is described. The remarkable regiocontrol of these cycloadditions that yield stable 1:1 cycloadducts is discussed on the basis of steric interactions into the pyrimido[4,5-c]isoquinoline-7,10-quinones. The access to angucyclinone AB-pyridopyrimidine analogues from Diels-Alder adducts and preliminar evidences on their antitumour activities are also reported.
A straightforward access to angucyclinone AB-pyridopyrimidine analogues 15 from acylhydroquinones 4 and aminouracil 6 and preliminary evidence of their antitumour activity are reported.
Journal: Tetrahedron Letters - Volume 49, Issue 4, 21 January 2008, Pages 703-706