کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5275722 1385540 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design and synthesis of angucyclinone AB-pyrido[2,3-d] pyrimidine analogues
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design and synthesis of angucyclinone AB-pyrido[2,3-d] pyrimidine analogues
چکیده انگلیسی

The preparation of two pyrimido[4,5-c]isoquinoline-7,10-quinones from acylhydroquinones and 1,3-dimethyl-5-aminouracil and their cycloadditions with 1-trimethylsilyloxybutadiene and 1-dimethylamino-3-methyl-1-azabutadiene is described. The remarkable regiocontrol of these cycloadditions that yield stable 1:1 cycloadducts is discussed on the basis of steric interactions into the pyrimido[4,5-c]isoquinoline-7,10-quinones. The access to angucyclinone AB-pyridopyrimidine analogues from Diels-Alder adducts and preliminar evidences on their antitumour activities are also reported.

A straightforward access to angucyclinone AB-pyridopyrimidine analogues 15 from acylhydroquinones 4 and aminouracil 6 and preliminary evidence of their antitumour activity are reported.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 49, Issue 4, 21 January 2008, Pages 703-706
نویسندگان
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