کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5275837 | 1385543 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Csp3-tellurium copper cross-coupling: synthesis of alkynyl tellurides a novel class of antidepressive-like compounds
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We present here the results on the synthesis of functionalized alkynyl tellurides using the reaction of vinyl, alkynyl, and aryl tellurides with several alkynyl iodides catalyzed by copper iodide. The reaction proceeded cleanly under mild reaction conditions, at room temperature, in the absence of base and ligand giving alkynyl tellurides in acceptable yields. The obtained compounds 3a-c and 3m-o were screened for antidepressive-like activity using the tail suspension test (TST) in mice. Compounds 3a-c and 3m-o administered at 10Â mg/kg by oral route produced a significant antidepressant-like effect on the TST in mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 50, Issue 8, 25 February 2009, Pages 909-915
Journal: Tetrahedron Letters - Volume 50, Issue 8, 25 February 2009, Pages 909-915
نویسندگان
Afamefuna Elvis Okoronkwo, Benhur Godoi, Ricardo Frederico Schumacher, José Sebastião Santos Neto, Cristiane Luchese, Marina Prigol, Cristina Wayne Nogueira, Gilson Zeni,