Biginelli reaction beyond three-component limit: synthesis of functionalized pyrimidinones via a one-pot Biginelli-Pd mediated C-C coupling strategy

A new and one-pot synthesis of novel alkynyl/alkenyl/aryl (hetero)aryl substituted 3,4-dihydropyrimidin-2(1H)-one derivatives has been developed via a multi-component reaction involving sequential phosphorus acid-mediated solvent-free Biginelli followed by copper-free Sonogashira or Heck or Suzuki reaction.