Organocatalytic asymmetric aza-Michael reaction: enantioselective addition of O-benzylhydroxylamine to chalcones

An organocatalytic enantioselective aza-Michael reaction is described. O-Benzylhydroxylamine adds to chalcones in the presence of a chiral thiourea catalyst, giving access to useful β-hydroxylamino ketones in good yields and moderate ee's.