کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5275905 1385545 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The synthesis and biological activity of novel spiro-isoxazoline C-disaccharides based on 1,3-dipolar cycloaddition of exo-glycals and sugar nitrile oxides
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
The synthesis and biological activity of novel spiro-isoxazoline C-disaccharides based on 1,3-dipolar cycloaddition of exo-glycals and sugar nitrile oxides
چکیده انگلیسی

A series of novel spiro-isoxazoline C-disaccharides were synthesized by the key step of 1,3-dipolar cycloaddition reactions of exo-glycals and sugar nitrile oxides, and followed by catalytic debenzylation in the presence of Pd(OH)2/C. The cycloaddition reactions were carried out stereoselectively and afforded α-isomers exclusively except in the case of galactose. The biological activities of the novel disaccharides against the glycosidases (α-amylase, α-glucosidase, and β-glucosidase) and HIV and BVDV were evaluated.

A series of novel spiro-isoxazoline C-disaccharides were synthesized by the 1,3-dipolar cycloaddition reactions of exo-glycals to sugar nitrile oxides, and their glycosidase inhibitory and antiviral activities were also evaluated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 48, Issue 44, 29 October 2007, Pages 7813-7816
نویسندگان
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