کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5276076 | 1385549 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pyruvoyl, a novel amino protecting group on the solid phase peptide synthesis and the peptide condensation reaction
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In one of the peptide condensation methods termed thioester method, an amino protecting group is required in the lysine side chain. In this study, to investigate the efficiency of the pyruvoyl group as an amino protecting group, we synthesized Nα-fluorenylmethoxycarbonyl (Fmoc)-Nε-pyruvoyl-lysine and introduced it into peptides and glycopeptides by the ordinary Fmoc-based solid phase peptide synthesis. The pyruvoyl peptide could be condensed with a peptide thioester by the thioester method, and this protecting group was easily removed by o-phenylenediamine treatment without significant side reactions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 50, Issue 7, 18 February 2009, Pages 818-821
Journal: Tetrahedron Letters - Volume 50, Issue 7, 18 February 2009, Pages 818-821
نویسندگان
Hidekazu Katayama, Takumi Utsumi, Chinatsu Ozawa, Yuko Nakahara, Hironobu Hojo, Yoshiaki Nakahara,