Copper-free PdCl2/PPh3-catalyzed Sonogashira coupling reaction of aryl bromides with terminal alkynes in water

A simple, copper-free and efficient catalytic system for the Sonogashira coupling reaction of aryl bromides with terminal alkynes in pure water has been developed. The use of PdCl2/PPh3 in the presence of pyrrolidine allows the coupling reaction to proceed at 120 °C in moderate to excellent yields.

A simple, copper-free and efficient catalyst system for the Sonogashira coupling reaction of aryl bromides with terminal alkynes in water has been developed. The use of PdCl2/PPh3 in the presence of pyrrolidine allows the coupling reaction to proceed at 120 °C with moderate to excellent yields.