Application of intramolecular Dötz reaction to the synthesis of ansa-compounds: concise synthesis of arnebinol

Fischer carbene complexes having long alkynyloxy chains regioselectively produced oxametacyclophanes via the intramolecular Dötz reaction. The utility of this reaction was demonstrated in the synthesis of arnebinol, an ansa-type terpenoid, from geranyl acetate in six steps.