Efficient total synthesis of (+)-exo-, (−)-endo-brevicomin and their derivatives via asymmetric organocatalysis and olefin cross-metathesis

The catalytic enantioselective synthesis of (+)-exo-, (−)-endo-brevicomin and their derivatives is described herein. This approach involves the use of the organocatalyzed asymmetric α-aminoxylation of aldehyde, in situ indium mediate allyation and olefin cross-metathesis. This versatile strategy allows for the rapid synthesis of other members of this class of natural products.