An azamacrocyclic receptor as efficient polytopic chiral solvating agent for carboxylic acids

The efficient use of a polyazamacrocycle as chiral solvating agent (CSA) for the determination of the enantiomeric excess of different carboxylic acids has been studied. All the data agree with the formation of multimolecular diastereomeric complexes in solution, which render good splitting of the NMR signals for the enantiomers of the acids (up to ΔΔδ = 0.20 ppm) using a small amount (even 0.125 equiv) of the receptor.