Stereoselective total synthesis of furofuran lignans through dianion aldol condensation

Highly stereoselective total synthesis of (+)-eudesmin, (+)-yangambin, (−)-eudesmin, and (−)-yangambin is described. This method is useful to generate the core skeleton of furofuran rings utilizing modification of Evans asymmetric aldol condensation.

Stereoselective total synthesis of (+)-eudesmin, (+)-yangambin, (−)-eudesmin, and (−)-yangambin is described.