The synthesis and conformational analysis of amino acid–tetrahydroanthranilic acid hybrids

The optimization of a palladium-catalyzed amidation reaction providing a new class of amino acid–tetrahydroanthranilic acid derivatives has been achieved. The scope of the reaction and preliminary conformational analysis of the resulting series of molecules is discussed.

The optimization of a palladium-catalyzed amidation reaction providing a new class of amino acid–tetrahydroanthranilic acid derivatives has been achieved. The scope of the reaction and preliminary conformational analysis of the resulting series of molecules is discussed.Figure optionsDownload as PowerPoint slide