کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5277179 | 1385574 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A Fmoc-based submonomeric strategy for the solid phase synthesis of optically pure chiral PNAs
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A Fmoc-based submonomeric strategy for the solid phase synthesis of optically pure chiral PNAs A Fmoc-based submonomeric strategy for the solid phase synthesis of optically pure chiral PNAs](/preview/png/5277179.png)
چکیده انگلیسی
A new submonomeric approach for the Fmoc solid phase synthesis of chiral PNAs is reported here. The design and synthesis of a new d-lysine-based Fmoc submonomer obtained by replacing the nucleobase residue with an Alloc group, compatible with Fmoc chemistry, is described starting from d-lysine and Fmoc-aminoacetaldehyde. The desired submonomer was obtained in high yield with no racemization. The conditions for synthesizing a chiral PNA dimer on solid support by a submonomeric approach have been optimized, allowing to obtain the desired PNA with a very high optical purity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 49, Issue 33, 11 August 2008, Pages 4958-4961
Journal: Tetrahedron Letters - Volume 49, Issue 33, 11 August 2008, Pages 4958-4961
نویسندگان
Tullia Tedeschi, Stefano Sforza, Francesca Maffei, Roberto Corradini, Rosangela Marchelli,