کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5277464 | 1385581 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sequential three-component reactions: synthesis, regioselectivity and application of functionalized dihydropyridines (DHPs) for the creation of fused naphthyridines
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Facile and efficient synthesis of tetrasubstituted 1,4- and 1,6-dihydropyridines (DHPs) has been achieved by employing three-component domino reaction using dimethyl acetylenedicarboxylate (DMAD), aliphatic amines, and α,β-unsaturated aldehyde in the presence of 30 mol % trifluoroacetic acid. Interestingly, regioselectivity for the synthesis of 1,4-dihydropyridines can be increased by using 30 mol % triflic acid. In addition, the synthesis of fused-naphthyridine derivatives has been accomplished involving imino-Diels–Alder reaction by employing 1,4-dihydropyridines, aromatic aldehydes, and aromatic amines.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 52, Issue 27, 6 July 2011, Pages 3455–3459
Journal: Tetrahedron Letters - Volume 52, Issue 27, 6 July 2011, Pages 3455–3459