Synthesis of 7- and 10-spermine conjugates of paclitaxel and 10-deacetyl-paclitaxel as potential prodrugs

Two conjugates at the 7- and 10-positions of paclitaxel and 10-deacetyl-paclitaxel with polyamine spermine have been synthesized. The low cytotoxicity evaluated in MCF7 and MCF7-R cell lines suggests that these conjugates could act as potential prodrugs.