High throughput evaluation of the production of substituted acetylenes by the Sonogashira reaction followed by the Mizoroki-Heck reaction in ionic liquids, in situ, using a novel array reactor

The parallel Sonogashira coupling reaction was carried out under copper-free condition by integrating the advantages of ionic liquids as the reaction media followed by the simultaneous-multiple Mizoroki-Heck reaction in situ by the use of a novel array reactor (SynArray-24). The device provides rapid evaluation of reactions in a short period.