کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5277907 | 1385591 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diastereoselective synthesis of polyfunctionalized piperidines as precursors of dopamine transporter imaging agents
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Diastereoselective synthesis of polyfunctionalized piperidines as precursors of dopamine transporter imaging agents Diastereoselective synthesis of polyfunctionalized piperidines as precursors of dopamine transporter imaging agents](/preview/png/5277907.png)
چکیده انگلیسی
The design and synthesis of a new kind of precursors of radiolabelled tracer agents for dopamine transporters imaging is described. The concept is based on the possibility of introducing the radioelement far from the sites of recognition and on the fact that only the labelled marker could cross the blood brain barrier to reach the dopamine transporters. For this purpose, a polyfunctionalized piperidine was synthesized bearing two aldehyde functions in the configuration allowing the formation of a tropane analog after the introduction of complexing moieties and complexation of a radioactive metal.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 48, Issue 9, 26 February 2007, Pages 1609-1612
Journal: Tetrahedron Letters - Volume 48, Issue 9, 26 February 2007, Pages 1609-1612
نویسندگان
Françoise Riché, Fadi Masri, Monique Lopez,