کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5277940 1385592 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Baylis-Hillman-derived N,N′-disubstituted piperazines: structural and preliminary computational studies
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Baylis-Hillman-derived N,N′-disubstituted piperazines: structural and preliminary computational studies
چکیده انگلیسی
Exploratory studies towards the preparation of potential HIV-1 protease and integrase inhibitors have led to the synthesis of Baylis-Hillman-derived N,N′-disubstituted piperazines. X-ray crystallographic, computer modelling and NMR techniques have been used to elucidate questions concerning configurational preferences, reaction pathways and the apparent difference in susceptibility towards aza-Michael reactions exhibited by methyl acrylate and methyl vinyl ketone (MVK) derived Baylis-Hillman substrates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 52, Issue 23, 8 June 2011, Pages 2972-2976
نویسندگان
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