کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5278133 | 1385597 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lipase-catalyzed kinetic resolution of thiotetronic acid derivatives bearing a chiral quaternary carbon: total synthesis of (R)-thiolactomycin and its O-analogue
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
We have developed a chemoenzymatic synthesis of (R)-thiolactomycin (1) having a chiral quaternary carbon atom at C5. In the kinetic resolution of the thiotetronic acid precursor 4, both enantiomers were obtained with high enantiomeric excess by use of Chirazyme® L-2. Chemical transformations of the (R)-alcohol 4 provided the chiral (R)-thiolactomycin (1) in 36% yield in five steps.
Lipase-catalyzed kinetic resolution of thiotetronic acid derivatives having a quaternary carbon was investigated. Total synthesis of (R)-thiolactomycin from (R)-alcohol was achieved in 36% yield in five steps.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 47, Issue 40, 2 October 2006, Pages 7163-7166
Journal: Tetrahedron Letters - Volume 47, Issue 40, 2 October 2006, Pages 7163-7166
نویسندگان
Ken-ichi Toyama, Tetsuo Tauchi, Nobuyuki Mase, Hidemi Yoda, Kunihiko Takabe,