Catalyst economy. Part 2: Sequential metathesis-Kharasch sequences using the Grubbs metathesis catalysts

Sequential ring-closing metathesis (RCM)-Kharasch cyclizations are promoted by the Grubbs metathesis catalysts and provide rapid access to bicyclic lactones and lactams.

The Grubbs metathesis catalysts have been shown to participate in sequential metathesis-Kharasch sequences.