A simple, highly regioselective, one-pot stereoselective synthesis of tertiary α-hydroxyesters: a tandem oxidation/benzilic ester rearrangement

This letter describes a simple, highly regioselective, stereoselective one-pot tandem oxidation/benzilic ester rearrangement protocol for the conversion of α-hydroxyketones to tertiary α-hydroxyesters.

This letter describes the synthesis of α-hydroxyketones and their stereoselective conversion to chiral tertiary α-hydroxyesters via a simple, highly regioselective, one-pot tandem oxidation/benzilic ester rearrangement protocol.