کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5278731 | 1385610 | 2009 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cyclic oligomers (macroaldonolactones) from a protected d-galactonic acid monomer Cyclic oligomers (macroaldonolactones) from a protected d-galactonic acid monomer](/preview/png/5278731.png)
Dicyclohexylcarbodiimide-promoted self-condensation of 2,3:4,5-di-O-isopropylidene-d-galactonic acid (3) led to the macrocyclic oligomeric cyclo[(2,3:4,5-di-O-isopropylidene-(1â6)-d-galactonate)2] (4) and cyclo[(2,3:4,5-di-O-isopropylidene-(1â6)-d-galactonate)3] (5), having, respectively, 14- and 21-membered rings. The macrocycles 4 and 5 were also synthesized by cyclization of the respective linear dimer 11 and trimer 14 Ï-hydroxy acids precursors prepared by stepwise additions of 3. Compounds 4 and 5 are biomaterials that may be described as macrolactone-cyclodextrins.
Macrocyclic lactones 4 and 5 were prepared by cyclization of the respective dimer and trimer linear precursors obtained by self-condensation of the d-galactonic acid derivative 3.
Journal: Tetrahedron Letters - Volume 50, Issue 40, 7 October 2009, Pages 5677-5680