The first total synthesis and structural determination of actinopyrone A

Actinopyrone A (1) has been synthesized by using our developed remote stereoinduction, Kocienski olefination, Horner–Wadsworth–Emmons olefination, and reductive de-conjugation of the vinylpyrone. A concise method of O-methylation to obtain the γ-pyrone has also been established.

Figure optionsDownload as PowerPoint slide